Exocellular Peptides from Antarctic PsychrophilePseudoalteromonas Haloplanktis |
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Authors: | Maya Mitova Maria Luisa Tutino Giuseppe Infusini Gennaro Marino Salvatore De Rosa |
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Affiliation: | (1) Istituto di Chimica Biomolecole CNR, via Campi Flegrei, 34, I-80078 Pozzuoli, (Napoli), Italy;(2) Institute of Organic Chemistry with Center of Phytochemistry, BAN, acad. Georgi Bonchev str., block 9, 1113, Sofia, Bulgaria;(3) Dipartimento di Chimica Organica e Biochimica Università di Napoli Federico II, via Cinthia, 4 I-80126, Napoli, Italy |
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Abstract: | A novel diketopiperazine, named cyclo-(D-pipecolinyl-L-isoleucine) (DKP 1), and 7 known diketopiperazines were isolated from the cell-free culture supernatant of the Antarctic psychrophilic bacterium Pseudoalteromonas haloplanktis TAC125. Two diketopiperazines containing pipecolinyl moiety were isolated for the first time from a natural source. Two new linear peptides, stable to bacterial proteolytic enzymes, were also characterized. The structures of the isolated compounds were elucidated by means of spectroscopic data (1D-, 2D-NMR, EIMS, FABMS, and ESIMS/MS) and chiral high-performance liquid chromatography. The potential antioxidant activity of the isolated compounds was evaluated by a DPPH free radical scavenging assay. |
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Keywords: | marine bacteria cyclodipeptides peptides Pseudoalteromonas haloplanktis |
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