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Effect of immunomodulators of various origin on the histamine-sensitizing activity of whole-cell pertussis vaccine] |
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| Authors: | N S Zakharova I B Shepeleva M V Britsina G S Vlasov N G Kalina S I Elkina T N Remova E V Ermolova I G Bazhanova S Ia Savranskaia |
| Abstract: | Changes in the histamine-sensitizing activity of whole-cell pertussis vaccine (PV) under the action of immunomodulators (IM) of bacterial (peptide and peptidoglycans), synthetic (peptidoglycan) and vegetable origin have been studied. The study has revealed that these IM, introduced orally and parenterally, exhibit histamine-sensitizing activity, depending on the nature of IM and the optimum selection of the doses of IM and PV. |
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