Effect of citrate on the different reactions catalyzed by rat mammary gland acetyl CoA carboxylase |
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| Authors: | P M Ahmad F Ahmad |
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| Institution: | 1. Membrane Bioenergetics Group, Lawrence Berkeley Laboratory and Department of Physiology-Anatomy, University of California, Berkeley, California 94720 USA;2. Membrane Bioenergetics Group, Lawrence Berkeley Laboratory and Department of Biophysics, University of California, Berkeley, California 94720 USA |
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| Abstract: | The effect of citrate on the different reactions catalyzed by rat mammary gland acetyl CoA carboxylase has been investigated. Citrate showed modest effect on the ATP-orthophosphate and ATP-ADP exchange reactions. In contrast, this tricarboxylic acid caused marked concentration-dependent stimulation of the acetyl CoA-malonyl CoA exchange reaction which was concomitant with the activation of acetyl CoA carboxylation. The data obtained are consistent with the suggestion that activation by citrate of the overall forward reaction (malonyl CoA synthesis) primarily reflects enhancement of the carboxyltransferase half-reaction catalyzed by rat mammary gland acetyl CoA carboxylase. |
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| Keywords: | Author to whom all correspondence should be addressed |
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