Synthesis of a coumarin based fluorescent amino acid |
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| Authors: | Guodong Sui Péter Kele Jhony Orbulescu Qun Huo and Roger M Leblanc |
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| Institution: | (1) Center for Supramolecular Science and Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, 33124, U.S.A;(2) Center for Supramolecular Science and Department of Chemistry, University of Miami, 1301 Memorial Drive, Coral Gables, 33124, U.S.A. |
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| Abstract: | L-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid (L-Adp), as a non-proteinogenic fluorescent amino acid has been synthesized by a highly stereoselective routine (>99.5%). This fluorescent amino acid, as fluorophore-quencher pair, may be used to study peptide assays. For enantiomeric excess determination, the racemic D-Adp (D-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid) has also been synthesized. |
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| Keywords: | coumarin fluorescence spectra fluorescent label fluorophore-quencher |
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