Inhibition by coumadin anticoagulants of enzymatic outer ring monodeiodination of iodothyronines |
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| Authors: | A Goswami J L Leonard I N Rosenberg |
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| Affiliation: | 1. Department of Medicine, Framingham Union Hospital, Framingham, Massachusetts, USA.;2. Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA. |
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| Abstract: | Iodothyronine outer ring monodeiodinase activity in rat kidney microsomes is strongly inhibited by the coumarin anticoagulants dicoumarol and warfarin. The inhibition is competitive with respect to the substrates and uncompetitive with respect to the thiol activator, dithiothreitol. Kinetic studies reveal that the mechanism of this inhibition is distinct from that obtained with propylthiouracil. This new class of iodine-free inhibitors may be useful in investigations of the mechanism of iodothyronine deiodination and in pharmacological studies of hormone metabolism. |
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