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Convenient method for determining the absolute configuration of chiral alcohols with racemic 1H NMR anisotropy reagent,M(alpha)NP acid: use of HPLC-CD detector |
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| Authors: | Kasai Yusuke Watanabe Masataka Harada Nobuyuki |
| Affiliation: | Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Aoba, Sendai, Japan. |
| Abstract: | A convenient method for determining the absolute configuration of chiral secondary alcohols using the racemic NMR anisotropy reagent, (+/-)-2-methoxy-2-(1-naphthyl)propionic acid [(+/-)-M(alpha)NP acid], and an HPLC-CD detector was developed. The method was successfully applied to some chiral alcohols derived from (-)-alpha-santonin. |
| Keywords: | chiral secondary alcohols racemic derivatizing agent 2‐methoxy‐2‐(1‐naphthyl)propionic acid diastereomeric esters HPLC separation 1H NMR anisotropy effect α‐santonin derivatives |
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