Microcephalic cerebrum with hypomyelination in the growth hormone-deficient mouse (lit) |
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Authors: | Tetsuya Noguchi Tetsuro Sugiasaki Yasuzo Tsukada |
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Affiliation: | (1) Department of Physiology, Toho University School of Medicine, Ohmori-nishi, 143 Tokyo;(2) Department of Physiology, Keio University School of Medicine, Shinanomachi, 160 Tokyo, Japan |
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Abstract: | To determine whether GH has an independent action on cerebral development, we examined the central nervous system of thelittle mouse (lit), a promissing model of isolated growth hormone deficiency. Our findings are (A); the weights of two parts of thelit brain were significantly less than those of the normal controls, 81.5% less for the cerebrum, and 81.6% for the cerebellum, (B): the total DNA content was reduced to approximately 80% in the cerebrum and 84% in the cerebellum compared to those of the normal controls, (C); the total RNA content was also reduced in the cerebrum and cerebellum, proportional to the reduction in DNA, (D); CNPase activity was reduced selectively in the cerebrum of thelit mouse (74.4% of the normal control), and (E); thelit mice exhibited a strikingly reduced level of activity with an indistinct diurnal periodicity. These results indicate that GH has independent actions on cerebral development, especially on glial cell proliferation as a precondition of myelin formation.Dedicated to Professor Yasuzo Tsukada. |
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