Evidence for two types of binding of 3H-gaba and 3H-muscimol in rat cerebral cortex and cerebellum.期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Evidence for two types of binding of 3H-gaba and 3H-muscimol in rat cerebral cortex and cerebellum.

Authors:	M Herschel R J Baldessarini

Institution:	Department of Psychiatry, Harvard Medical School Boston, and Mailman Laboratories, McLean Division of Massachusetts General Hospital, Belmont, MA 02178, USA

Abstract:	The binding of n $M$ concentrations of ³HGABA and ³Hmuscimol to synaptosomal membrane preparations from different areas of rat brain were studied by a radioreceptor assay. The characteristics of binding, with respect to kinetic parameters and inhibition of binding by nonradioactive GABA, before and after detergent treatment, suggest the presence of at least two types of binding at putative GABA receptor sites.

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