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Hepatoprotection by L-cysteine-glutathione mixed disulfide,a sulfhydryl-modified prodrug of glutathione |
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| Authors: | Berkeley Lorelle I Cohen Jonathan F Crankshaw Daune L Shirota Frances N Nagasawa Herbert T |
| Institution: | Medical Research Laboratories, DVA Medical Center, Minneapolis, MN 55417, USA. |
| Abstract: | L-Cysteine-glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen-induced hepatotoxicity. Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated. |
| Keywords: | Acetaminophen Hepatotoxicity Prodrugs L‐Cysteine‐Glutathione Disulfide |
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