Effect of tetraphenylboron on the calcium-dependent ATPase activity of sarcoplasmic reticulum |
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Authors: | F Soler F Fernandez-Belda J C Gomez-Fernandez |
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Affiliation: | Departamento de Bioquimica y Biologia Molecular, Universidad de Murcia, Spain. |
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Abstract: | The apparent effect of tetraphenylboron on the Ca2+-dependent ATPase activity is rather complex being dependent of the physical state of the membrane. In leaky vesicles, tetraphenylboron decreases the affinity of the enzyme for Ca2+, and high concentrations (100 microM) inhibit the enzyme. These effects are mediated by the membrane structure. In native vesicles, tetraphenylboron induces an apparent stimulation of the maximum hydrolytic activity and a decrease of the Ca2+ gradient formed due to specific Ca2+ releasing activity of the mentioned drug. |
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