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The use of the orthotopic model to validate antivascular therapies for cancer |
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| Authors: | Loi Monica Di Paolo Daniela Becherini Pamela Zorzoli Alessia Perri Patrizia Carosio Roberta Cilli Michele Ribatti Domenico Brignole Chiara Pagnan Gabriella Ponzoni Mirco Pastorino Fabio |
| Affiliation: | Laboratory of Oncology, G. Gaslini Children's Hospital, Genoa, Italy. |
| Abstract: | The orthotopic model reproduces aspects of the tumour microenvironment and emulates a number of important biological features of cancer progression, angiogenesis, metastasis and resistance. Due to its parallels with human cancer, the model can be used to evaluate therapeutic responses to various therapies. This review outlines the importance of using the orthotopic implantation of tumour cells in mice models for evaluating the effectiveness of antivascular therapies. |
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