Ephecting excitatory synapse development |
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| Authors: | Dalva Matthew B |
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| Affiliation: | Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA. dalva@mail.med.upenn.edu |
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| Abstract: | Alterations in synapse number and morphology are associated with devastating psychiatric and neurologic disorders. In this issue of Cell, Margolis et?al. (2010) show that the RhoA-guanine exchange factor (GEF) Ephexin5 limits the numbers of excitatory synapses that neurons receive, thus identifying a new mechanism controlling synaptogenesis. |
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