|
|||||
|
|
Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium |
|
| Authors: | Thaddeus S Stappenbeck Melissa H Wong Jennifer R Saam Indira U Mysorekar Jeffrey I Gordon |
| Institution: | Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA |
| Abstract: | The mouse intestinal epithelium undergoes rapid renewal throughout life, thereby requiring continuous coordination of its cellular proliferation, differentiation, and death programs. Recent advances in our understanding of this process have highlighted some of the molecules that regulate renewal and their potential roles in gut neoplasia. |
| Keywords: | Abbreviations: APC adenomatous polyposis coli Fkh6 forkhead homolog 6 GALT gut-associated lymphoid tissue GLP-2 glucagon-like peptide 2 Gsk-3β glycogen synthase kinase-3β JP juvenile polyposis LOH loss of heterozygosity Min multiple intestinal neoplasia MMR mismatch repair Shh Sonic hedgehog TGFβ transforming growth factor β |
| 本文献已被 ScienceDirect 等数据库收录！ | |