Assessment of circulating biochemical markers and antioxidative status in acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients |
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Authors: | Mahmood Rasool Shahzad Farooq Arif Malik Aysha Shaukat Abdul Manan Muhammad Asif Suleman Sani Mahmood Husain Qazi Mohammad Amjad Kamal Zafar Iqbal Abrar Hussain |
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Institution: | 1. Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia;2. Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan;3. Department of Biotechnology and Informatics, BUITEMS, Quetta, Pakistan;4. Centre for Research in Molecular Medicine (CRiMM), The University of Lahore, Lahore, Pakistan;5. King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia;6. College of Applied Medical Sciences, King Saud Bin Abdulaziz University of Health Sciences, National Guards Health Affairs, Riyadh, Saudi Arabia |
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Abstract: | Various circulating biochemical markers are indicators of pathological state in leukemia and its subtypes. Increased oxidative stress and decreased antioxidant factors portray clear image associated with malignancies during subtypes of leukemia. In this research work we investigated the inter-relationship among the subtypes of leukemia with circulating biochemical markers and oxidative stress in the Pakistani population. This research work was conducted on a total number of 70 subjects in which 20 were control participants and 50 were suffering from leukemia and divided into two subtypes (ALL and AML). Various circulating biomarkers were investigated including hematological, hepatic and renal profiles as well as oxidative stress markers, electrolytes and vitamins C and E. Results show that vitamin E was found to be decreased in diseased sub-types (P < 0.05). Malondialdehyde (MDA) levels were very high in disease sub-types (ALL-B = 8.69 ± 1.59; ALL-T = 8.78 ± 0.97; AML = 8.50 ± 1.29) compared to controls (1.22 ± 0.10; P < 0.05) while the levels of antioxidants superoxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GSH), catalase (CAT)], platelets, as well as electrolytes (Ca and Mg) were reduced in patients suffering from leukemia (sub-types). Enhanced levels of oxidative stress (MDA) and decreased levels of enzymatic and non-enzymatic antioxidants reflect the pathological state and impaired cell control in patients suffering from leukemia (subtypes) and show a strong correlation with oxidative stress, indicating that patients’ biological systems are under oxidative stress. |
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Keywords: | Leukemia ALL AML MDA Antioxidants Oxidative stress Electrolytes |
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