An overview on the correlation of neurological disorders with cardiovascular disease |
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| Authors: | C.K. Firoz Nasimudeen R. Jabir Mohd Shahnawaz Khan Maged Mahmoud Shazi Shakil Ghazi A. Damanhouri Syed Kashif Zaidi Shams Tabrez Mohammad A. Kamal |
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| Affiliation: | aKing Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia;bProtein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia;cDepartment of Bioengineering, Integral University, Kursi Road, Lucknow, UP 226026, India;dCenter of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia |
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| Abstract: | Neurological disorders (NDs) are one of the leading causes of death especially in the developed countries. Among those NDs, Alzheimer’s disease (AD) and Parkinson disease (PD) are heading the table. There have been several reports in the scientific literatures which suggest the linkage between cardiovascular disorders (CVDs) and NDs. In the present communication, we have tried to compile NDs (AD and PD) association with CVDs reported in the literature. Based on the available scientific literature, we believe that further comprehensive study needs to be done to elucidate the molecular linking points associated with the above mentioned disorders.Abbreviations: AD, Alzheimer’s disease, Aβ, β amyloid, PD, Parkinson disease, l-DOPA, l-dihydroxyphenylalanine, LBs, Lewy bodies, DA, dopamine, APP, amyloid precursor protein, CVD, cardiovascular disease |
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| Keywords: | Neurological disorders, Alzheimer’ s disease, Parkinson disease, Cardiovascular disease, Aβ , Dopamine, α -Synuclein |
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