MiR-203 Suppresses ZNF217 Upregulation in Colorectal Cancer and Its Oncogenicity |
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| Authors: | Zewu Li Lutao Du Zhaogang Dong Yongmei Yang Xin Zhang Lili Wang Juan Li Guixi Zheng Ailin Qu Chuanxin Wang |
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| Institution: | Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, Shandong Province, China.; The University of Hong Kong, CHINA, |
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| Abstract: | Zinc finger protein 217 (ZNF217) is essential for cell proliferation and has been implicated in tumorigenesis. However, its expression and exact roles in colorectal cancer (CRC) remain unclear. In this study, we demonstrated that ZNF217 expression was aberrantly upregulated in CRC tissues and associated with poor overall survival of CRC patients. In addition, we found that ZNF217 was a putative target of microRNA (miR)-203 using bioinformatics analysis and confirmed that using luciferase reporter assay. Moreover, in vitro knockdown of ZNF217 or enforced expression of miR-203 attenuated CRC cell proliferation, invasion and migration. Furthermore, combined treatment of ZNF217 siRNA and miR-203 exhibited synergistic inhibitory effects. Taken together, our results provide new evidences that ZNF217 has an oncogenic role in CRC and is regulated by miR-203, and open up the possibility of ZNF217- and miR-203-targeted therapy for CRC. |
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