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Untying a Knotted SPOUT RNA Methyltransferase by Circular Permutation Results in a Domain-Swapped Dimer
Affiliation:1. Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan;2. Institute of Bioinformatics and Structural Biology, National Tsing Hua University, Hsinchu 30013, Taiwan;3. Department of Medical Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan;4. Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan
Abstract:
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  • Keywords:knotted protein  circular permutation  domain swap  protein folding  X-ray crystallography  small angle X-ray scattering  hydrogen-deuterium exchange mass spectrometry
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