Synthesis and biological evaluation of glucose conjugated phthalocyanine as a second-generation photosensitizer |
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| Institution: | 1. Department of Materials Science, National Institute of Technology, Yonago College, Yonago, Tottori 683-8502, Japan;2. Department of Biomedical Sciences, Tottori University, Yonago, Tottori 683-8503, Japan;3. Department of Material Science, Graduate School of Science, Osaka City University, Osaka 558-8585, Japan;1. Department of Organic and Pharmaceutical Technology, Faculty of Chemistry, Wroclaw University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wroclaw, Poland;2. Department of Molecular and Cellular Biology, Wroclaw Medical University, Borowska 211A, 50-556, Wroclaw, Poland;3. Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, Sienkiewicza 21, 50-335, Wroclaw, Poland;1. Faculty of Chemistry, Jagiellonian University, 30-060 Kraków, Poland;2. TÜBITAK Marmara Research Center, Materials Institute, P.O. Box 21, 41470 Gebze, Kocaeli, Turkey;3. Gebze Technical University, Department of Chemistry, P.O. Box 141, 41400 Gebze, Kocaeli, Turkey;1. College of Chemistry, State Key Laboratory of Photocatalysis on Energy and Environment, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou, 350116, China;2. Department of Pharmacy, The Affiliated First Hospital of Fujian Medical University, Fuzhou, 350001, China;3. School of Chemistry, University of New South Wales, Sydney, NSW, 2052, Australia;1. Institute of Chemistry, University of Opole, ul. Oleska 48, 45-052 Opole, Poland;2. Institute of Medical Sciences, University of Opole, ul. Oleska 48, 45-052 Opole, Poland |
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| Abstract: | Photodynamic therapy (PDT) is a treatment method using light and photosensitizers (PSs), which is categorized as a non-invasive surgery treatment for cancers. When the tumor is exposed to a specific light, the PSs become active and generate reactive oxygen species (ROS), mainly singlet oxygen which kills nearby cancer cells. PDT is becoming more widely recognized as a valuable treatment option for localized cancers and pre-cancers of skin as it has no long-term effects on the patient. But, due to the limited penetration rate of light into the skin and other organs, PDT can’t be used to treat large cancer cells or cancer cells that have grown deeply into the skin or other organs. Hence, in this study, our focus centers on synthesizing glucose-conjugated phthalocyanine (Pc) compatible with near-infrared (NIR) irradiation as second-generation photosensitizer, so that PDT can be used in a wider range to treat cancers without obstacles. |
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| Keywords: | Photodynamic therapy (PDT) Photosensitizers (PSs) Hypoxia Phthalocyanine (Pc) Near-infrared (NIR) irradiation Glucose |
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