首页 | 本学科首页   官方微博 | 高级检索  
     


Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14
Affiliation:1. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA;3. Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02215, USA;4. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA;5. Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;6. Daegu-Gyeongbuk Medical Innovation Foundation, Republic of Korea;7. Chemical Kinomics Research Center, Korea Institute of Science and Technology, Republic of Korea;8. KU-KIST Graduate School of Converging Science and Technology, Korea University, Republic of Korea;1. Dementia Drug Resource Development Center, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan;2. Natural Products Chemistry Research Group, Program Study of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia;1. Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou 310013, China;2. Hangzhou Hertz Pharmaceutical Co., Hangzhou 310018, China;1. Graduate School of Science, Osaka Prefecture University, Osaka 599-8531, Japan;2. Whol Institute for Drug Discovery of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, The Weizmann Institute of Science, Rehovot 7610001, Israel;3. Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel;1. Department of Medicinal Chemistry, Acerta Pharma BV, Kloosterstraat 9, 5349 AB Oss, the Netherlands;2. Department of Biology and Translational, Acerta Pharma BV, Kloosterstraat 9, 5349 AB Oss, the Netherlands;1. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA;2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA;3. Blais Proteomics Center, Dana-Farber Cancer Institute, Boston, MA 02115, USA;4. Department of Pathology, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA 02215, USA;5. Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
Abstract:
Keywords:Covalent kinase inhibitor  CDK14  TAIRE kinase  CDK15  CDK16  CDK17  CDK18  CDK inhibitor  Mitosis  Cell cycle
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号