Synthesis and comparison of substituted 1,2,3-dithiazole and 1,2,3-thiaselenazole as inhibitors of the feline immunodeficiency virus (FIV) nucleocapsid protein as a model for HIV infection |
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| Institution: | 1. Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore;2. Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, MBB/Biokemi-Floor 9A, Solnavägen 9, SE-17165 Solna, Stockholm, Sweden;3. Shiv Nadar University, NH91, Tehsil Dadri, Greater Noida, Gautam Buddha Nagar, 201314, India |
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| Abstract: | We report the first biological evaluation the 1,2,3-thiaselenazole class of compound and utilising a concise synthetic approach of sulfur extrusion, selenium insertion of the 1,2,3-dithiazoles. We created a small diverse library of compounds to contrast the two ring systems. This approach has highlighted new structure activity relationship insights and lead to the development of sub-micro molar anti-viral compounds with reduced toxicity. The 1,2,3-thiaselenazole represents a new class of potential compounds for the treatment of FIV and HIV. |
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| Keywords: | Feline immunodeficiency virus (FIV) Human immunodeficiency virus (HIV) Selenium Zinc ejection Nucleocapsid protein |
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