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Risk factors for acquisition of extended spectrum beta lactamase producing Escherichia coli and Klebsiella pneumoniae in North-Indian hospitals |
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| Authors: | Sibhghatulla Shaikh Jamale Fatima Shazi Shakil Syed Mohd Danish Rizvi Mohammad Amjad Kamal |
| Institution: | aDepartment of Biosciences, Integral University, Lucknow 226026, India;bDepartment of Bio-Engineering, Integral University, Lucknow 226026, India;cKing Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia;dEnzymoic, 7 Peterlee Pl, Hebersham, NSW 2770, Australia |
| Abstract: | Multidrug resistance and production of extended spectrum β-lactamases (ESBLs) by enteric gram negative rods in hospitals and community continue to be a matter of scientific concern. This retrospective study was executed to assess the prevalence of ESBL-producing Escherichia coli and Klebsiella pneumoniae at two North Indian hospitals and to determine the risk factors associated with the acquisition of these organisms. A total of 346 bacterial isolates were obtained. Of these, 48.27% (n = 167) were confirmed to be ESBL producers while 51.73% (n = 179) were non ESBL-producers. Among the ESBL producers, 55.69% (n = 93) were E. coli and 44.31% (n = 74) were K. pneumoniae. ESBL producing isolates showed co-resistance to multitude of antibiotics tested. Length of hospital stay (>3 days) and previous exposure to antibiotics were found as significant risk factors (p = 0.01 and 0.02) associated with the acquisition of ESBL-producing E. coli and K. pneumoniae isolates. Imipenem and meropenem can be suggested as drugs of choice in our study. |
| Keywords: | Antibiotics ESBLs Escherichia coli Imipenem Multidrug resistance Risk factors |
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