High-throughput screening of bioactive compounds via new catalytic reaction in the pooled mixture |
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| Affiliation: | 1. Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, kita-ku, Okayama 700-8530, Japan;2. Research Core for Interdisciplinary Sciences, Okayama University, 3-1-1 Tsushima-naka, kita-ku, Okayama 700-8530, Japan;3. CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, Strasbourg 67000, France |
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| Abstract: | To increase the chances of finding new candidate molecules with medicinal properties, while expending less resource and effort, the present study used pooled substrates as starting materials. A bisindole compound that showed inhibitory activity was then isolated from the mixture, and the activity was improved by optimizing the substituents on the indole skeleton. |
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| Keywords: | Golgi Secretion Brefeldin A Bisindole High-throughput screening |
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