PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis |
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Authors: | Zhang Jun Xu Liang-Guo Han Ke-Jun Wei Xudong Shu Hong-Bing |
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Institution: | National Jewish Medical and Research Center, 1400 Jackson Street, k516c, Denver, CO 80206, USA. |
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Abstract: | The TIR domain-containing adapter protein TRIP is critically involved in TLR3-induced IFN-β production through activation of NF-κB and ISRE. In addition, TRIF also induces apoptosis when overexpressed in 293 cells. In this report, we demonstrate that PIASy, a member of the PIAS SUMO-ligase family, interacts with TRIP, IRF-3 and IRF-7. In reporter gene assays, PIASy dramatically inhibits TRIF-induced NF-κB, ISRE and IFN-β activation but not TRIF-induced apoptosis. Furthermore, PIASy also inhibits IRF-3, IRF-7 and Sendai virus-induced ISRE activation. Our results suggest that PIASy is an inhibitor of TRIF-induced ISRE and NF-κB activation but not apoptosis. |
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Keywords: | PIASy TRIP ISRE IFN-β NF-κB |
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