Cerebrospinal fluid flow and iodide131 transport in the spinal subarachnoid space |
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Authors: | Robert M. Post Frank H. Allen Ayub K. Ommaya |
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Affiliation: | 1. Chief, 3-West Clinical Research Unit, Adult Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland 20014, USA;7. Chief, Diagnostic Section, Nuclear Medicine, Bethesda, Maryland 20014, USA;71. Surgical Neurology Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014, USA |
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Abstract: | Free Na131 I and 131I-Albumin were injected in the cisterna magna of rhesus monkeys. The dynamics of descent into the spinal subarachnoid space and transport out of the cerebrospinal fluid were determined by gamma scintigraphy. 131I-Albumin moved slowly caudally, reaching the sacral CSF in three hours. Free Na131I was rapidly absorbed locally and did not descend. When its transport out of cerebrospinal fluid was inhibited by the addition of unlabeled isotonic Na I, 131I descended slowly at a rate parallel to that of tagged albumin. Injection of Na131I in hypertonic solutions caused immediate descent. Two minute periods of tumbling activity caused rapid movement of Na131I and 131I-Albumin into the lumbar spinal fluid. Na131I dynamics may serve as a model for other molecules actively transported out of cerebrospinal fluid, such as 5-hydroxy-indoleacetic acid; descent into caudal spinal fluid may depend on the degree of efflux from cerebrospinal fluid and on the animal's activity. |
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Keywords: | Reprint requests to: Building 10 Room 3S239 National Institute of Mental Health Bethesda Maryland 20014 (Dr. Post). |
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