Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit |
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| Affiliation: | 1. Cancer Research UK Drug-DNA Interactions Research Group, UCL Cancer Institute, London, WC1E 6BT, UK;2. Department of Chemistry, Hope College, Holland, MI 49423, United States;3. Department of Chemistry, Georgia State University, Atlanta, GA 30303, United States |
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| Abstract: | The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for the fused pyrrole found in the DNA alkylation subunit. |
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| Keywords: | Duocarmycin Yatakemycin CC-1065 DNA alkylation |
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