Cytoprotective small molecule modulators of endoplasmic reticulum stress |
| |
Institution: | 1. Department of Physiology, Faculty of Science, Charles University in Prague, Czech Republic;2. Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic |
| |
Abstract: | Cellular health depends on the normal function of the endoplasmic reticulum (ER) to fold, assemble, and modify critical proteins to maintain viability. When the ER cannot process proteins effectively, a condition known as ER stress ensues. When this stress is excessive or prolonged, cell death via apoptotic pathways is triggered. Interestingly, most major diseases have been shown to be intimately linked to ER stress, including diabetes, stroke, neurodegeneration, and many cancers. Thus, controlling ER stress presents a significant strategy for drug development for these diseases. The goal of this review is to present various small molecules that alleviate ER stress with the intention that they may serve as useful starting points for therapeutic agent development. |
| |
Keywords: | ER stress Endoplasmic reticulum Drug discovery Small molecules Medicinal chemistry |
本文献已被 ScienceDirect 等数据库收录! |
|