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Synthetic approaches to the 2014 new drugs
Affiliation:1. Pfizer Worldwide Research and Development, Groton Laboratories, 445 Eastern Point Road, Groton, CT 06340, United States;2. Pharmacodia (Beijing) Co., Ltd, Beijing 100085, China;3. Celgene Avilomics Research, 200 Cambridge Park Drive, Cambridge, MA 02140, United States;4. China Novartis Institutes for BioMedical Research Co., Ltd, Shanghai 200131, China;5. BioDuro Co., Ltd, Shanghai 200131, China;1. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt;2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Ain Helwan, Cairo, Egypt;3. Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ain Helwan, University Campus, 11795 Cairo, Egypt;4. Center for Scientific Excellence ‘Helwan Structural Biology Research (HSBR)’, Cairo, Egypt;1. Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China;2. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China;1. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China;2. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China;1. Department of Medical Science, Soonchunhyang University, Asan, Chungnam 31538, South Korea;2. Department of Pharmaceutical Engineering, Soonchunhyang University, Asan, Chungnam 31538, South Korea;3. R & D Institute, Daewon Pharm. Co. Ltd., Seoul 04808, South Korea;4. Crystallization and Particle Science, Institute of Chemical and Engineering Sciences, A*STAR, Jurong Island, Singapore 627833, Singapore;1. Junior Research Group for Microbial Biotechnology, Ruhr-University Bochum, 44780, Bochum, Germany;2. Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Yokohama, 223-8522, Japan;3. Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010, Graz, Austria;1. School of Pharmacy, Fudan University, Shanghai 201203, PRChina;2. Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Shanghai 201203, PRChina;3. Shanghai Medicilon Inc., 585 Chuanda Road, Shanghai 201299, PRChina;4. Jiangsu Aosaikang Pharmaceutical CO., LTD, 699 Kejian Road, Nanjing, 211112, P.R. Jiangsu, PRChina
Abstract:New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition and also serve as leads for designing future new drugs. This annual review covers the synthesis of thirty-seven NCEs that were approved for the first time in 2014 and one drug which was approved in 2013 and was not covered in a previous edition of this review.
Keywords:Synthesis  New drug molecules  New chemical entities  Medicine  Therapeutic agents
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