Antiplasmodial phloroglucinol derivatives from Syncarpia glomulifera |
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| Affiliation: | 1. Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States;2. Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, United States;3. Natural Products Discovery Institute, Doylestown, PA 18902, United States;1. Dipartimento di NEUROFARBA, Sezione di Farmaceutica e Nutraceutica, Università degli Studi di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy;2. Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717, USA;3. Department of Chemistry, Imperial College London, South Kensington, London SW7 2AZ, UK;4. Department of Biotechnology and Organic Chemistry, Tomsk Polytechnic University, Tomsk 634050, Russia;5. Department of Chemistry, Altai State Technical University, Barnaul, Russia;6. Institute of Chinese Medical Sciences, University of Macau, Macau;1. Department of Pharmacognosy, College of Pharmacy, Cairo University, Cairo, 11562, Egypt;2. Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, 89081, Ulm, Germany;1. School of Pharmacy, Guiyang Medical University, Guiyang 550004, China;2. School of Pharmacy, Guizhou University, Guiyang 550025, China;1. Chair of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, University of Jena, Philosophenweg 14, D-07743 Jena, Germany;2. Organic Chemistry II, Saarland University, Campus C 4.2, D-66123 Saarbrücken, Germany;3. Institute for Inorganic Chemistry, Saarland University, Campus C 4.1, D-66123 Saarbrücken, Germany |
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| Abstract: | Bioassay guided fractionation of a MeOH extract of the stem bark of Syncarpia glomulifera (Myrtaceae) led to the isolation of the two new phloroglucinol derivatives (±)-rhodomyrtosone F (1) and (±)-calliviminone C (2), the three known triterpenes, betulinic acid (3), ursolic acid-3-acetate (4), and ursolic acid (5), and 1-(2,4,6-trihydroxyphenyl)-1-hexanone (6). Compound 1 exhibited strong antiplasmodial activity, while compounds 2–4 were moderately active and 5 and 6 were inactive in this assay. The structures of 1 and 2 were elucidated based on analyses of their mass spectrometric data, 1D and 2D NMR spectra, and comparison with related compounds. |
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| Keywords: | Antiplasmodial activity Phloroglucinol |
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