Animal models in the pharmacokinetic/pharmacodynamic evaluation of antimicrobial agents |
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| Institution: | 1. Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium;2. Ghent University, Ghent, Belgium;3. Department of Pharmacy, Mount Sinai West Hospital, New York, United States;4. University of Queensland Centre for Clinical Research, The University of Queensland, Brisbane, Australia;5. Department of Intensive Care Medicine, Royal Brisbane and Women''s Hospital, Brisbane, Australia;6. Department of Laboratory Medicine, Ghent University Hospital, Ghent, Belgium;7. Department of Diagnostic Sciences, Ghent University, Ghent, Belgium;8. Department of Pharmacy, Royal Brisbane and Women''s Hospital, Brisbane, Australia;9. Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Australia;1. School of Medicine, Griffith University, Gold Coast, Queensland 4222, Australia;2. Centre for Translational Anti-Infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Woolloongabba, Queensland, Australia;3. Faculty of Medicine, The University of Queensland, Brisbane, Queensland 4006, Australia;4. Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland 4111, Australia;5. Gold Coast Health, Southport, Queensland 4215, Australia |
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| Abstract: | Animal infection models in the pharmacokinetic/pharmacodynamic (PK/PD) evaluation of antimicrobial therapy serve an important role in preclinical assessments of new antibiotics, dosing optimization for those that are clinically approved, and setting or confirming susceptibility breakpoints. The goal of animal model studies is to mimic the infectious diseases seen in humans to allow for robust PK/PD studies to find the optimal drug exposures that lead to therapeutic success. The PK/PD index and target drug exposures obtained in validated animal infection models are critical components in optimizing dosing regimen design in order to maximize efficacy while minimize the cost and duration of clinical trials. This review outlines the key components in animal infection models which have been used extensively in antibiotic discovery and development including PK/PD analyses. |
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| Keywords: | Pharmacokinetics Pharmacodynamics Animal model Drug development |
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