Depletion of secretory granules,calcitonin, and formaldehyde-ozone-induced fluorescence from cat thyroid C cells by vitamin D2 treatment |
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Authors: | R Håkanson A Melander Ch Owman F Sundler |
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Institution: | (1) Departments of Pharmacology and Histology, University of Lund, Lund, Sweden |
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Abstract: | Summary Using a combination of electron microscopy, fluorometry, and bioassay, the C cells of the cat thyroid were investigated with respect to their content of secretory granules, and calcitonin, and to their formaldehyde-ozone-induced fluorescence. This fluorescence is assumed to reflect the presence of a peptide with NH2-terminal tryptophan. In cats injected with large doses of vitamin D2 daily for 5 days, the C cells were degranulated, their fluorescence intensity was lowered and the calcitonin content of the thyroid was markedly reduced. It is suggested that the proposed tryptophyl peptide in the C cells is stored in the secretory granules and that it is engaged in the storage and/or release of the hormone. |
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