Chemotaxonomic significance of lignans from Serissa japonica (Thunb.) Thunb |
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| Affiliation: | 1. School of Pharmacy, North China University of Science and Technology, Tangshan, 063210, People''s Republic of China;2. Department of Pharmacy, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China;3. Nanjing Medical Center for Clinical Pharmacy, Nanjing, 210008, Jiangsu Province, China;1. Department of Pharmacognosy, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000, Sofia, Bulgaria;2. Department of Biology, Science Faculty, Selcuk University, Konya, Turkey;3. Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, 2 Dunav Str., 1000, Sofia, Bulgaria;1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China;2. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, PR China;1. Department of Organic Chemistry, Faculty of Science, The University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon;2. Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical Sciences, University of Johannesburg, P.O. Box 1711, Doornfontein, Johannesburg, 2028, South Africa;3. Center for Natural Product Research (CNPR), Chemical Sciences Department, University of Johannesburg, 2028, South Africa;4. Research Center for Synthesis and Catalysis; Department of Chemical Sciences, University of Johannesburg-Kingsway Campus, Auckland Park, 2008, South Africa;5. Laboratory of Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, The University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon;6. Laboratory of Pharmacology, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, P.O. Box 13033, Yaoundé, Cameroon;7. Laboratoire de chimie des Substances naturelles, Muséum National d’Histoire Naturelle, 63 Rue Buffon, 75005, Paris, France;1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. Key Laboratory of Structure-Based Drug Design & Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, PR China;3. Anhui Institute for Food and Drug Control, Hefei 230051, PR China |
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| Abstract: | Sixteen known lignans were isolated from the 95% alcohol extract of the whole plant of Serissa japonica (Thunb.) Thunb., including nine furofurans (1–9), three tetrahydrofurans (10–12) and four arylnaphthalenes (13–16). In the present report, compounds (+)-epipinoresinol (1), (+)-1-hydroxy-6-epipinoresinol 4,4″-di-O-methyl ether (3), (−)-pinoresinol (4), (+)-8-hydroxypinoresinol (6), pseuderesinol (7), (+)-1-hydroxysyringaresinol (8), (−)-(7′S,8S,8′R)-4,4′-dihydroxy-3,3′,5,5′-tetramethoxy-7′,9-epoxylignan-9′-ol-7-one (10), wikstrone (11), 7'-(+)-oxomatairesinol (12), (+)-cycloolivil (13), (+)-isolariciresinol (14), 5-methoxy-(+)-isolariciresinol (15) and cyclolignans (16) were reported from the Serissa genus for the first time, and compounds (+)-lirioresinol A (2) and (−)-lirioresinol B (5) were firstly isolated from the plant. Their structures were elucidated on the basis of extensive spectroscopic and chemical analyses. Moreover, the chemotaxonomic significance of the isolated compounds is discussed. |
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| Keywords: | Lignans Chemotaxonomic |
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