Chemotaxonomic significance of lindenane sesquiterpenoid dimers and eudesmane sesquiterpenoids from Chloranthus henryi Hemsl. var. hupehensis (Pamp.) K. F. Wu |
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| Institution: | 1. School of Pharmacy, North China University of Science and Technology, Tangshan, 063210, People''s Republic of China;2. Department of Pharmacy, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China;3. Nanjing Medical Center for Clinical Pharmacy, Nanjing, 210008, Jiangsu Province, China;1. Joint Surgery, Guangxi Orthopaedics and Traumatology Hospital, Nanning, 530000, Guangxi Zhuang Autonomous Region, PR China;2. Graduate School, Guangxi University of Chinese Medicine, Nanning, 530000, Guangxi Zhuang Autonomous Region, PR China;3. Orthopedics and Traumatology College, Guangxi University of Chinese Medicine, Nanning, 530001, Guangxi Zhuang Autonomous Region, PR China;4. Department of Orthopedics, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 53000, Guangxi Zhuang Autonomous Region, PR China;5. Joint Surgery, International ZhuangYi Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, 530000, Guangxi Zhuang Autonomous Region, PR China;1. State Key Laboratory of Quality Research in Chinese Medicine, Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, People''s Republic of China;2. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, People''s Republic of China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China;2. Institute of Medicinal Chemistry and Chemical Biology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China;3. Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China;1. College of Pharmacy, South-Central University for Nationalities, Wuhan 430074, PR China;2. Eskitis Institute, School of Biomolecular and Physical Sciences, Griffith University, QLD 4111, Brisbane, Australia;1. Department of Pharmacy, Jiangsu Ocean University, Lianyungang, 222000, Jiangsu, PR China;2. China Tobacco Henan Industrial Co. Ltd, Zhengzhou, 450000, Henan, PR China;3. Jiangsu Marine Pharmaceutical Resources Development Engineering Research Center, Lianyungang, 222000, Jiangsu, PR China;4. Jiangsu Magic Medicine Co., Ltd, Lianyungang, 222006, Jiangsu, PR China |
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| Abstract: | Seventeen known compounds were isolated from the 95% alcohol extract of the aerial parts of Chloranthus henryi Hemsl. var. hupehensis (Pamp.) K. F. Wu, including five lindenane sesquiterpenoid dimers (1–5) and twelve eudesmane sesquiterpenoids (6–17). In the present research, compounds 3 sarcaglabrin C, 6 neolitacumone C, 7 ent-Atractylenolide III and 8 dehydrocarissone were reported from the Chloranthus genus for the first time, and compounds 1 spicachlorantin B, 2 chloramultilide C, 4 shizukaol B, 5 japonicone C, 9 6α-hydroxyeudesma-4(15),7(11),8(9)-triene-12,8-olide, 10 ent-(3R)-3-hydroxyatractylenolide III, 11 8βH-hydroxyeudesma-4(14),7(11)-dien-12,8-olide, 12 lasianthuslactone A, 13 (5S,6R,8S,10R)-6-hydroxyeudesma-4(15),7(11)-diene-12,8-olide, 14 4β-hydroxy5α,8β(H)-eudesm-7(11)-en-8,12-olide, 15 4β,8β-dihydroxy-5α(H)-eudesm-7(11)-en-8,12-olide, 16 curcolonol and 17 1β, 8β-dihydroxyeudesm - 3,7(11)-dien-8α,12-olide were firstly isolated from the plant. Their structures were elucidated on the basis of extensive spectroscopic and chemical analyses. Moreover, the chemotaxonomic significance of the isolated compounds is discussed. |
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| Keywords: | Sesquiterpenoid dimers Eudesmane sesquiterpenoids Chemotaxonomic |
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