Antibacterial and antioxidant activities of compounds isolated from the leaves of Symphonia globulifera (Clusiaceae) and their chemophenetic significance |
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| Affiliation: | 1. Department of Organic Chemistry, Faculty of Science, The University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon;2. Drug Discovery and Smart Molecules Research Laboratory, Department of Chemical Sciences, University of Johannesburg, P.O. Box 1711, Doornfontein, Johannesburg, 2028, South Africa;3. Center for Natural Product Research (CNPR), Chemical Sciences Department, University of Johannesburg, 2028, South Africa;4. Research Center for Synthesis and Catalysis; Department of Chemical Sciences, University of Johannesburg-Kingsway Campus, Auckland Park, 2008, South Africa;5. Laboratory of Phytobiochemistry and Medicinal Plants Studies, Faculty of Science, The University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon;6. Laboratory of Pharmacology, Centre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies, P.O. Box 13033, Yaoundé, Cameroon;7. Laboratoire de chimie des Substances naturelles, Muséum National d’Histoire Naturelle, 63 Rue Buffon, 75005, Paris, France;1. School of Pharmacy, North China University of Science and Technology, Tangshan, 063210, People''s Republic of China;2. Department of Pharmacy, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China;3. Nanjing Medical Center for Clinical Pharmacy, Nanjing, 210008, Jiangsu Province, China;1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China;2. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, 110032, PR China;1. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, 541004, China;2. Medical College, Guangxi University of Science and Technology, Liuzhou, 545006, Guangxi, China;1. School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, PR China;2. Biological Testing Laboratory of Tianjin Tiancheng Drug Assessment Research Co., Ltd., Tianjin, 300301, PR China |
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| Abstract: | The phytochemical study was done on the methanol extract from of the leaves of Symphonia globulifera. This plant has been used in traditional medicine to treat of different ailments such as malaria, diseases of the skin, diabetes, cough, intestinal worms, pre-hepatic jaundice and fever. Chromatographic fractionation and purification of this extract led to the isolation and characterization of twelve compounds (1–12) including pristriol (1), robustaflavone (2), polycarpol (3), 7''-O-methylrobustaflavone (4), amentoflavone (5), stigmasterol glucoside (6), epicatechin (7), apigenin (8), luteolin (9), 1,5-dihydroxyxanthone (10), β-sitosterol 3-β-D-glucopyranoside (11) and a mixture of stigmasterol and β-sitosterol (12). The structures of compounds 1–12 were elucidated on the basis of 1D and 2D NMR, mass spectrometric and the spectroscopic data as well as comparison with the literature. All these compounds were isolated for the first time from Symphonia genus. The NMR spectra and structure elucidation of compound 1 were reported for the first in the literature. The antibacterial and antioxidant activities of three of these compounds were evaluated. The chemophenetic significance of these compounds is also discussed. |
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| Keywords: | Clusiaceae Pristriol Antibacterial activity |
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