Synaptonemal complex stability depends on repressive histone marks of the lateral element-associated repeat sequences |
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Authors: | Abrahan Hernández-Hernández Rosario Ortiz Ernestina Ubaldo Olga M Echeverría Martínez Gerardo H Vázquez-Nin Félix Recillas-Targa |
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Institution: | 1. Laboratorio de Microscopía Electrónica, Departamento de Biología Celular, Facultad de Ciencias, Universidad Nacional Autónoma de México (UNAM), México D.F., C.P. 04510, Mexico 2. Instituto de Fisiología Celular, Departamento de Genética Molecular, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-242, México D.F., C.P. 04510, Mexico
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Abstract: | The synaptonemal complex (SC) is the central key structure for meiosis in organisms undergoing sexual reproduction. During
meiotic prophase I, homologous chromosomes exchange genetic information at the time they are attached to the lateral elements
by specific DNA sequences. Most of these sequences, so far identified, consist of repeat DNA, which are subject to chromatin
structural changes during meiotic prophase I. In this work, we addressed the effect of altering the chromatin structure of
repeat DNA sequences mediating anchorage to the lateral elements of the SC. Administration of the histone deacetylase inhibitor
trichostatin A into live rats caused death of cells in the pachytene stage as well as changes in histone marks along the synaptonemal
complex. The most notable effect was partial loss of histone H3 lysine 27 trimethylation. Our work describes the epigenetic
landscape of lateral element-associated chromatin and reveals a critical role of histone marks in synaptonemal complex integrity. |
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