Functional characterization of a small heat shock protein from <Emphasis Type="Italic">Mycobacterium leprae</Emphasis> |
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| Authors: | Nirmala Lini Elengikal Abdul Azeez Rehna Sugathan Shiburaj Jayapal Jeya Maheshwari Nallakandy Panagadan Shankernarayan Kuppamuthu Dharmalingam |
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| Institution: | (1) Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India;(2) Applied Microbiology and Microbial Technology Lab, Tropical Botanical Garden Research Institute, Palode, Thiruvanathapuram-695562, Kerala, India;(3) Voluntary Health Services, Leprosy Project, Shaktinagar, Periyar District, 638315 Tamil Nadu, India |
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| Abstract: | Background Small heat shock proteins are ubiquitous family of stress proteins, having a role in virulence and survival of the pathogen.
M. leprae, the causative agent of leprosy is an uncultivable organism in defined media, hence the biology and function of proteins
were examined by cloning M. leprae genes in heterologous hosts. The study on sHsp18 was carried out as the knowledge about the functions of this major immunodominant
antigen of M. leprae is scanty. |
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