An achiral (oligo)nucleotide analog |
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| Authors: | M. J. van Vliet J. Visscher Alan W. Schwartz |
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| Affiliation: | (1) Evolutionary Biology Research Group, Faculty of Science, University of Nijmegen, Toernooiveld 1, 6525 ED, Nijmegen, The Netherlands |
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| Abstract: | An achiral nucleotide analog based on barbituric acid has been synthesized. The analog, which is 5,5-di(2-phosphoethyl)barbituric acid, undergoes extensive oligomerization in aqueous solution, when activated, to produce pyrophosphate-linked chains. In contrast to a number of other bisphosphorylated nucleoside analogs which have been studied, the compound has little tendency to cyclize. The possible prebiotic implications are discussed. Correspondence to: AM. Schwartz |
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| Keywords: | Nucleotide analogs Oligomerization Chirality Barbituric acid Pentaerythritol Prebiotic chemistry |
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