CRM1-mediated nuclear export: to the pore and beyond |
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| Authors: | Hutten Saskia Kehlenbach Ralph H |
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| Institution: | 1. Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;2. Biochemistry and Molecular Biophysics Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;3. Joint first authors;1. Institute of Pediatric Research, Children''s Hospital of Soochow University, Suzhou, 215025, China;2. Department of Pediatric Surgery, Children''s Hospital of Soochow University, Suzhou, 215025, China;1. Laboratoire de Biologie moléculaire du gène (CP300), Faculté des Sciences, Université Libre de Bruxelles (ULB), Belgium;2. Center for Microscopy and Molecular Imaging (CMMI), 6041 Gosselies, Belgium |
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| Abstract: | CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin beta superfamily of nuclear transport receptors, recognizing proteins bearing a leucine-rich nuclear export sequence. CRM1 is the major receptor for the export of proteins out of the nucleus and is also required for transport of many RNAs. Besides its established role in nuclear export, CRM1 is also implicated in various steps during mitosis, widening its functional spectrum within the cell. |
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