Biochemical polymorphism in the rat: Genetics of three electrophoretic variants and characterization of inbred strains |
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| Authors: | L. F. M. van Zutphen A. Lagerwerf J. Bouw M. G. C. W. den Bieman |
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| Affiliation: | (1) Vakgroep Zoötechniek, Department of Animal Genetics, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 17, Utrecht, The Netherlands;(2) Central Institute for the Breeding of Laboratory Animals—TNO, Woudenbergseweg 25, Zeist, The Netherlands |
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| Abstract: | Nine inbred strains of the rat (Rattus norvegicus) were screened for differences in electrophoretically detectable proteins. Interstrain variation was observed for 7 of 26 proteins. Three of these variants have not been described previously: leucine aminopeptidase (Lap-1), major urinary protein (Mup-1), and seminal vesicle protein (Svp-2). Genetic analysis revealed two autosomal alleles for each of these polymorphisms. The loci Lap-1, Mup-1, and Svp-2 are linked neither to one another nor to the previously described Svp-1 and Es-4 loci. Each of the nine strains can be identified now by a specific set of monogenic markers. |
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| Keywords: | genetics electrophoresis biochemical polymorphism strain characterization rat |
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