| 四种圆斑蝰蛇蛇毒对血小板聚集抑制作用的比较研究 |
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| 引用本文： | 包承鑫,Ronald A.Hutton. 四种圆斑蝰蛇蛇毒对血小板聚集抑制作用的比较研究[J]. 动物学研究, 1991, 0(1) |
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| 作者姓名： | 包承鑫 Ronald A.Hutton |
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| 作者单位： | 中国医学科学院血液学研究所 天津(包承鑫)，英国皇家免费医院 伦敦(Ronald A.Hutton) |
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| 摘 要： | 对四种不同来源的RVV对ADP、Col和Ris诱导的血小板聚集抑制作用进行比较研究。RVV-B,RVVS和RVV-Styp对三种诱导剂的血小板聚集均有抑制作用,而RVV-T虽有ADP和Col抑制作用,但缺乏对Ris的抑制活性。预先与RVV孵育的血小板经洗涤后重新悬浮于自身PPP中,与RVV-StyP孵育的血小板完全恢复对Ris的凝集反应,而与RVV-B和RVV-S孵育的血小板仅部分恢复其反应。上述结果表明,在RVV中可能含有二种不同的血小板聚集抑制活性,而其抑制机理可能牵涉到血小板、血浆等因素。
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| 关 键 词： | 圆斑蝰蛇蛇毒 血小板聚集抑制作用 |
COMPARATIVE STUDIES OF THE INHIBITION OF FOUR Vipera russelli VENOMS ON PLATELET AGGREGATION |
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| Bao Chengxin. COMPARATIVE STUDIES OF THE INHIBITION OF FOUR Vipera russelli VENOMS ON PLATELET AGGREGATION[J]. Zoological Research, 1991, 0(1) |
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| Authors: | Bao Chengxin |
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| Abstract: | The inhibition of RVV from different source on platelet aggregation induced by ADP, Collagen or Ristocetin were studied. RVV-B, RVV-S and RVV-Styp could inhibited aggregation induced by above reagents. RVV-T could inhibited aggregation induced by ADP and Collagen, but not by Ristocetin. Platelets preincubated with RVV were resuspended in PPP after washed. It was observed that platelets preincubated with RVV-Styp could entirely restored to respond to Ristocetin, but only partially with RVV-B and RVV-S.These results shown that two distinct platelet inhibitory activities in RVV exist, the mechanism of the inhibition could involved platelet, plasma and other factors. |
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| Keywords: | Vipera russelli venom Inhibitory action of platelet aggregation |
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