IGF-II binding on human lymphoid cells: demonstration of a common high affinity receptor for insulin like peptides |
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Authors: | R L Hintz A V Thorsson G Enberg K Hall |
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Institution: | 5. Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden |
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Abstract: | We have studied the binding of 125I-GF-II to the IM-9 human lymphoid cell line, and to human placental membranes. All of IGF-II radioligand binding to IM-9 cells, and half of the binding to human placental membranes is to a previously unrecognized common (Type-III) high affinity receptor site for insulin-like peptides, in which IGF-I and IGF-II are equipotent and insulin only slightly less potent. This common receptor represents another mechanism by which insulin, and the somatomedins can exert biological action. |
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