Direct stimulation of translation by the multifunctional herpesvirus ICP27 protein |
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Authors: | Larralde Osmany Smith Richard W P Wilkie Gavin S Malik Poonam Gray Nicola K Clements J Barklie |
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Institution: | MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom. |
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Abstract: | Herpes simplex virus type 1 (HSV-1) ICP27 protein is an essential regulator of viral gene expression with roles at various levels of RNA metabolism in the nucleus. Using the tethered function assay, we showed a cytoplasmic activity for ICP27 in directly enhancing mRNA translation in vivo in the absence of other viral factors. The region of ICP27 required for translational stimulation maps to the C terminus. Furthermore, in infected cells, ICP27 is associated with polyribosomes, indicating a function in translation during the lytic cycle. |
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