Evidence for the repair of potentially lethal damage in irradiated bone marrow |
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| Authors: | Frank Thomas Michael N Gould |
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| Institution: | (1) Department of Human Oncology, Wisconsin Clinical Cancer Center, University of Wisconsin, 600 Highland Avenue CHS - K4/310, 53792 Madison, WI, USA;(2) Present address: Department of Radiation Therapy, Cleveland Clinic, Cleveland, Ohio, USA |
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| Abstract: | Summary The effects on cell survival of maintaining bone marrow cells (CFU-S) in situ following irradiation and before assay by transplantation was investigated. When the CFU-S cells are maintained in situ following irradiation survival drops and plateaus at about 9 h post-irradiation. Evidence is presented that this decrease in survival may be due to potentially lethal damage repair (PLD) inhibition caused by post-irradiation in situ holding. This effect on PLD repair is different than that usually found in cells in vitro and in vivo tumors in that it mainly alters the shoulder rather than the slope of the survival curve of CFU-S cells. It is different than PLDR found in vivo for normal mammary and thyroid gland epithelial cells because in situ holding decreases rather than increases the survival of CFU-S cells. Evidence is also presented that the radiation survival curve for in situ bone marrow cells (CFU-S) may not have a shoulder.Supported in part by NIH, NCI grants P01 CA 19298 and P30 CA 14520Supported in part by an American Cancer Society Clinical Fellowship |
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