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Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels |
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| Authors: | Sohn Jong-Woo Xu Yong Jones Juli E Wickman Kevin Williams Kevin W Elmquist Joel K |
| Institution: | 1 Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA 2 Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA 3 Children''s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA 4 Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA 5 Department of Pharmacology, University of Minnesota, Minneapolis, MI 55455, USA |
| Abstract: | Serotonin 2C receptors (5-HT(2C)Rs) expressed by pro-opiomelanocortin (POMC) neurons of hypothalamic arcuate nucleus regulate food intake, energy homeostasis and glucose metabolism. However, the cellular mechanisms underlying the effects of 5-HT to regulate POMC neuronal activity via 5-HT(2C)Rs have not yet been identified. In the present study, we found the putative transient receptor potential C (TRPC) channels mediate the activation of a subpopulation of POMC neurons by mCPP (a?5-HT(2C)R agonist). Interestingly, mCPP-activated POMC neurons were found to be a distinct population from those activated by leptin. Together, our data suggest that 5-HT(2C)R and leptin receptors are expressed by distinct subpopulations of arcuate POMC neurons and that both 5-HT and leptin exert their actions in POMC neurons via TRPC channels. VIDEO ABSTRACT: |
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