Benzophenanthridine alkaloids from Zanthoxylum nitidum (Roxb.) DC, and their analgesic and anti-inflammatory activities |
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| Authors: | Hu Jiang Zhang Wei-Dong Liu Run-Hui Zhang Chuan Shen Yun-Heng Li Hui-Liang Liang Ming-Jin Xu Xi-Ke |
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| Affiliation: | Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China. |
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| Abstract: | Seven benzophenanthridine alkaloids, 1-7, were isolated from the roots of Zanthoxylum nitidum. Among them, two novel alkaloids, named (R)-8-[(R)-1-hydroxyethyl]dihydrochelerythrine (1) and 8-methoxynorchelerythrine (2), were structurally identified as new compounds on the basis of the spectroscopic analysis. Bioactivity evaluation showed that nitidine (3), dihydrochelerythrine (4), oxyavicine (5), 8-methoxychelerythrine (6), and 8-hydroxydihydrochelerythrine (7) exhibit comparable analgesic and anti-inflammatory effects as hydrocortisone. |
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| Keywords: | Zanthoxylum nitidum Alkaloids Benzophenanthridine alkaloids Anti‐inflammatory activity Analgesic activity |
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