Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines |
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| Authors: | Ding Hongxia Lu Wei Li Haibo Yang Leixiang Zhang Qijun Zhou Changxin Wu Xiumei Baudoin Olivier Cai Junchao Guéritte Françoise Zhao Yu |
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| Affiliation: | Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, PR China. |
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| Abstract: | Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10(-6) M scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed. |
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