Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines |
| |
Authors: | Ding Hongxia Lu Wei Li Haibo Yang Leixiang Zhang Qijun Zhou Changxin Wu Xiumei Baudoin Olivier Cai Junchao Guéritte Françoise Zhao Yu |
| |
Affiliation: | Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310031, PR China. |
| |
Abstract: | Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10(-6) M scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|