Polymerization of Tobacco Mosaic Virus Protein and its Control |
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Authors: | A. C. H. DURHAM A. KLUG |
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Affiliation: | 1.MRC Laboratory of Molecular Biology,Cambridge |
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Abstract: | Near neutral pH9 TMV protein sub-units polymerize into two-layer aggregates culminating in the 20S disk, whereas the helical rod forms cooperatively at acid pH. The mode of aggregation is controlled by the state of ionization of two abnormally titrating carboxyl groups. |
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