hMLH1基因启动子CpG岛甲基化致MSI与肿瘤的关系

通过人类错配修复基因( hMLHl)启动子CpG岛甲基化与微卫星不稳定性(MSI)的分析,探讨癌症发病的机制.错配修复基因hMLH1启动子CpG岛甲基化是hMLH1基因失活的重要机制,而hMLH1的表达失活则可导致MSI的产生,促进癌症的发生.根据一系列研究得出结论,在肿瘤组织中hMLH1基因启动子CpG岛甲基化和微卫星不稳定(MSI)有显著相关性,并在癌症早期发生、发展过程中起重要作用.因此临床检测hMLH1基因启动子CpG岛甲基化及微卫星不稳定可能成为癌症鉴别诊断、评价预后、指导化疗的分子标志物之一.

Cancer and microsatellite instability resulted from methylation of the hMLH1 promoter CpG island

We analysed the relation of the methylation of the hMLH1 promoter and microsatellite instability(MSI) in order to investigate the mechanism of cancer.Methylation of the hMLH1 promoter CpG island is an important factor resulting in the defection of mismatch repair gene,which gives rise to an production of MSI and promotes the occurrence of cancer.Based on a series of experiments,it can draw the conclusion that there is a significant correlation between methylation of the hMLH1 promoter CpG island,MSI status and cancer.Methylation of the hMLH1 promoter CpG island and MSI play an important role in the early occurrence and development of cancer.Therefore,the clinical testing of methylation of the hMLH1 promoter CpG island and MSI may be used as one of the cancer molecule markers for the differential diagnosis,prognostic evaluation and clinical medication.