| 29株耐亚胺培南和/或美罗培南鲍曼不动杆菌产碳青霉烯酶基因型检测 |
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| 引用本文： | 魏艳艳,熊自忠,邹桂舟. 29株耐亚胺培南和/或美罗培南鲍曼不动杆菌产碳青霉烯酶基因型检测[J]. 中国微生态学杂志, 2012, 24(9): 808-809,818 |
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| 作者姓名： | 魏艳艳 熊自忠 邹桂舟 |
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| 作者单位： | 1. 安徽医科大学第二附属医院肝病科,安徽合肥,230000
2. 安徽医科大学第一附属医院感染科,安徽合肥,230022 |
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| 基金项目： | 安徽省自然科学基金(050430804);安徽省优秀青年科技基金(08040106815) |
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| 摘 要： | 目的 了解临床分离耐亚胺培南和/或耐美罗培南鲍曼不动杆菌中产碳青霉烯酶的基因型别.方法 采用聚合酶链反应扩增IMP、VIM、OXA型碳青霉烯酶基因并测序.结果 29株对碳青霉烯类耐药的鲍曼不动杆菌中,以产OXA-24型和IMP型酶菌株最多,二者均占51.7％ (15/29).产OXA-24+ IMP型5株、OXA-24+ OXA-51+IMP型4株、VIM型4株、OXA-24+ OXA-58+ IMP型、OXA-23+ OXA-24+ IMP型各2株,OXA-23+IMP型、OXA-51+OXA-24型、OXA-24型、IMP型各1株,8株细菌PCR检测结果为阴性.结论 耐亚胺培南和/或美罗培南鲍曼不动杆菌主要产OXA-24型和IMP型碳青霉烯酶,部分菌株可同时产2种或以上碳青霉烯酶.
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| 关 键 词： | 鲍曼不动杆菌 碳青霉烯酶 基因型 |
The genetype of carbapenemase produced by imipenem-and/or meropenem-resistant Acinetobacter baumannii isolates |
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| WEI Yan-yan , XIONG Zi-zhong , ZOU Gui-zhou. The genetype of carbapenemase produced by imipenem-and/or meropenem-resistant Acinetobacter baumannii isolates[J]. Chinese Journal of Microecology, 2012, 24(9): 808-809,818 |
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| Authors: | WEI Yan-yan XIONG Zi-zhong ZOU Gui-zhou |
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| Affiliation: | 1(1.Department of Infectious Diseases,the Second and First Affiliated Hospitals,Anhui Medical University,Hefei 230022,China;2.The First Affiliafed Hospital,Anhui Medical University,Hefei 230000,China) |
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| Abstract: | Objective To investigate the genetype of carbapenemase produced by imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii strains clinical isolated.Methods A total of 29 strains of imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii were screened by PCR with primer pairs designed to detect genes encoding OXA-23,24,51,58 and VIM,IMP enzymes,respectively.Results In the 29 carbapenemase producers,OXA-24 and IMP were the most common,each accounting for 51.7%(15/29).The positive strains of OXA-24+IMP,OXA-24+OXA-51+IMP,VIM,OXA-24+OXA-58+IMP,OXA-23+OXA-24+IMP,OXA-23+IMP,OXA-51+OXA-24,OXA-24 and IMP were 5,4,4,2,2,1,1,1 and 1 strain,respectively.Conclusion OXA-24 and IMP are the main genotypes of carbapenemase in imipenem-resistant and/or meropenem-resistant Acinetobacter baumannii. |
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| Keywords: | Acinetobacter baumannii Carbapenemase Genetype |
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