Associated endocrine,physiological and behavioral changes in rhesus monkeys after intravenous corticotropin-releasing factor administration |
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Authors: | Ned H Kalin Steven E Shelton Gary W Kraemer William T McKinney |
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Institution: | 1. Psychiatry Section, William S. Middleton Memorial Veterans Hospital, Madison WI 53705, USA;2. Department of Psychiatry, University of Wisconsin-Madison, Madison, WI 53706, USA |
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Abstract: | The intravenous (IV) administration of synthetic ovine corticotropin-releasing factor (CRF) (10 and 125 μg/kg) to chair restrained rhesus monkeys stimulated the pituitary-adrenal axis. At these doses, increases in plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol were associated with blood pressure decreases and behavioral effects. These data demonstrate that synthetic ovine CRF (10 and 125 μg/kg) administered IV to the rhesus monkey results in associated endocrine, physiological, and behavioral changes. |
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Keywords: | Corticotropin-releasing factor (CRF) Intravenous Rhesus monkeys |
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