Distribution and origin of bombesin,substance P and somatostatin in cat spinal cord |
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Authors: | V.John Massari,Yousef Tizabi,Chan H. Park,Terry W. Moody,Cinda J. Helke,Thomas L. O Donohue |
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Affiliation: | 1. Department of Pharmacology, Howard University College of Medicine, Washington, DC 20059 USA;2. Department of Biochemistry, The George Washington University School of Medicine, Washington, DC 20037 USA;3. Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 USA;4. Experimental Therapeutics Branch, NINCDS, Bethesda, MD 20205 USA |
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Abstract: | Bombesin (BN), substance P-(SP) and somatostatin (SRIF) were measured in individual laminae of the cervical, thoracic and lumbar (L) spinal cord of control cats, and in the L6 segment of cats receiving a spinal hemisection (L2) or deafferentation via dorsal rhizotomy at L6, 7, S1. The interlaminar distribution of BN, SP, and SRIF was remarkably similar. Highest concentrations were found in the superficial dorsal horn, and progressively less was found proceeding ventrally. Some intersegmental variations in peptide concentration within a single lamina were found. Dorsal rhizotomy caused a significant decline in BN, SP and SRIF in lamina I-III, therefore all three peptides appear to be contained in dorsal root ganglion cells. Evidence is presented for the existence of ascending BN and SP projections originating in lamina I-III and VII, for a descending SRIF pathway terminating in lamina VIII, and for an ascending BN path in lamina VIII. Dorsal root afferents to lamina VIII influence levels of BN, SP and SRIF. |
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Keywords: | Cat spinal cord Substance P Somatostatin Bombesin |
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